Matrix metalloproteinases in atrial fibrillation: Reply
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منابع مشابه
Matrix metalloproteinases in atrial fibrillation.
We read with great interest the study by Boixel et al. (1), which examines the importance of matrix metalloproteinase (MMP) system in atrial remodeling in a rat model of heart failure. The investigators demonstrate the up-regulation of MMP-2 and MMP-9 in the atria with marked structural abnormalities, but there were no significant differences in tissue inhibitors of MMP (TIMP) activity. The cli...
متن کاملMatrix metalloproteinases and atrial structural remodeling.
Atrial fibrillation (AF) is a common arrhythmia, affecting approximately 5% of the population older than 65 years; the arrhythmia is associated with significant morbidity and mortality, and it is challenging and often frustrating to treat (1,2). There is a tendency for AF to become chronic and more resistant to cardioversion with increasing duration of the arrhythmia (3). Although the details a...
متن کاملP 88: Matrix Metalloproteinases in Neuroinflammation
Matrix metalloproteinases (MMPs) are a family of neutral proteinases that are important in normal development, cellular differentiation or migration, angiogenesis, neurogenesis, wound repair, and a wide range of pathological processes such as oxidative stress and neuroinflammation. MMPs have been demonstrated to increase the permeability of the blood–brain barrier (BBB) by degrading the c...
متن کاملAtrial extracellular matrix remodelling in patients with atrial fibrillation
UNLABELLED Atrial fibrillation (AF) is the most frequent clinical arrhythmia. Atrial fibrosis is an important factor in initiating and maintaining AF. However, the collagen turnover and its regulation in AF has not been completely elucidated. We tested the hypothesis that the extracellular matrix changes are more severe in patients with permanent AF in comparison with those in patients in sinus...
متن کاملAtrial extracellular matrix remodeling and the maintenance of atrial fibrillation.
BACKGROUND Remodeling occurs in both ventricle and atrium in dilated cardiomyopathy and heart failure. However, the alteration of atrial extracellular matrix components during remodeling and its effect on the electrical remodeling and atrial arrhythmia have never been explored. METHODS AND RESULTS Atrial tissue samples of 53 explanted hearts from patients with dilated cardiomyopathy and end-s...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2004
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2003.10.020